Document 0008
 DOCN  M9470008
 TI    Modification of lymphocyte subsets in the intestinal-associated immune
       system and thymus by chronic ethanol consumption.
 DT    9409
 AU    Lopez MC; Huang DS; Borgs P; Wang Y; Watson RR; Department of Family and
       Community Medicine, Arizona Health; Sciences Center, Tucson 85724.
 SO    Alcohol Clin Exp Res. 1994 Feb;18(1):8-11. Unique Identifier : AIDSLINE
       MED/94256603
 AB    Modification of the mucosa-associated intestinal immune system of female
       C57BL/6 mice was studied during consumption of the Lieber-DeCarli diet
       supplemented with 5% v/v ethanol or laboratory chow with ethanol (20%
       w/v) in the drinking water. All groups received ethanol for 11 weeks.
       Mice fed the Lieber-DeCarli diet had fewer CD8+ cells/villus than the
       chow-fed controls. Mice that received ethanol in the drinking water had
       fewer IgA-containing cells and CD8+ cells than controls. There were no
       differences in the number of cells in the mesenteric lymph nodes between
       ethanol-treated mice and their respective controls. Nevertheless,
       chow-fed control mice had more cells than those fed the Lieber-DeCarli
       control diet. Although no differences were detected in the percentages
       of CD4+, CD8+, LECAM-1+, and LECAM-1+ CD4+ cells, there was a decrease
       in the percentage of LECAM-1+ CD8+ cells in ethanol-fed mice when
       compared with their Lieber-DeCarli controls. Mice receiving ethanol in
       the drinking water showed alterations in the CD4 CD45RC subsets and in
       the CD8 CD45RC subsets. Similar results were observed in mice receiving
       Lieber-DeCarli diets alone or supplemented with ethanol. The low dose,
       chronic exposure of dietary ethanol in the Lieber-DeCarli-fed mice did
       not significantly affect the numbers of various thymocyte subsets. But,
       a decrease in the percentage of CD4- CD8+ cells was observed in the
       thymus of mice receiving ethanol in the drinking water. Chronic ethanol
       consumption caused significant decreases in the number of CD8+ and IgA+
       cells in the intestinal lamina propria, important in mucosal immune
       defenses.
 DE    Alcohol, Ethyl/*TOXICITY  Alcoholism/*IMMUNOLOGY  Animal  B-Lymphocyte
       Subsets/*DRUG EFFECTS/IMMUNOLOGY  CD4-CD8 Ratio/DRUG EFFECTS  Female
       Immune Tolerance/IMMUNOLOGY  Intestinal Mucosa/*IMMUNOLOGY  Leukocyte
       Count/DRUG EFFECTS  Lymph Nodes/IMMUNOLOGY  Mice  Mice, Inbred C57BL
       Peyer's Patches/*IMMUNOLOGY  Support, U.S. Gov't, P.H.S.  T-Lymphocyte
       Subsets/*DRUG EFFECTS/IMMUNOLOGY  Thymus Gland/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).